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ABO Incompatible Liver Transplantation - 1

Chairpersons - Mettu Srinivas Reddy, Shashwat Sarin

🗓️ 22 Nov 2025 🕒 9:00 - 9:35 📍Hall A

Theme - Immunology, Outcomes & Clinical Strategies in ABO Incompatible Liver Transplantation

Objectives -

• To understand the immunological principles of ABOi Liver Transplantation.
• To explore evolving trends and long-term outcomes in ABOi Liver Transplantation.
• To apply desensitization and management strategies in complex cases.

B Cell Immunology in ABO-Incompatible Liver Transplantation: Mechanisms, Monitoring, and Modulation

9:00 - 9:10 Introductory Talk

Speaker: Anil Arora

Case based Panel Discussion: 49-year-old alcoholic cirrhosis (MELD 28); Recipient B+; Donor A-; IgG anti-A 512; IgM anti-A 256

Sub-topics:

1. Pre-transplant risk stratification & significance of antibody titers (IgG/IgM)

2. Desensitization protocols: Rituximab, plasmapheresis, IVIG, bortezomib

3. Perioperative immunosuppression: induction & maintenance strategies

4. Monitoring antibody titers – thresholds for proceeding

5. Intra-operative considerations – graft selection, ischemia time

6. Post-operative care: infection risks vs rejection control

7. Rescue strategies in refractory AMR after ABOi Liver Transplantation

8. Long-term graft survival and quality of life

9:10 - 9:35 Panel Discussion

Moderator : Sanjiv Saigal

Panelists: Ankur Atal Gupta, Hitendra Garg, Niteen Kumar, Prashant Pandey, Radhika Venugopal

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