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Familial Cholestasis and Alagille Syndrome

Chairpersons - Ishaq Malik, Mohit Vora, Priti Vijay

🗓️ 21 Nov 2025 🕒 11:48 - 12:23 📍Hall C

Theme - From Biliary Diversion to Transplant: Evolving Treatment Paradigms

Objectives -

• Provide an overview of familial intrahepatic cholestasis (PFIC) and Alagille syndrome (ALGS), including recent advances in understanding
• Explore the living related donor dilemma in PFIC and ALGS separately
• Debate biliary diversion (internal vs. external) versus transplant as therapeutic strategies
• Review new medical therapies (IBAT inhibitors) and their potential to shift the treatment algorithm

Overview & What’s New: Genetics, natural history, and evolving indications for intervention in PFIC and ALGS

11:48 - 11:56 Talk

Speaker: Lalit Verma

Journey of a real world case

Sub Topic
1) Mutation specific prognosis and individualized transplant timing
2) Risk of heterozygous carriers as donors - Living related donor dilemma
3) ALGS: cardiac/vascular comorbidities in recipients and donor selection
4) Role of diversion procedures in pruritus relief, progression prevention, and how they compare with Liver Transplantation

11:56 - 12:11 Case-Based Panel Discussion

Moderator : Shivani Deswal

Panelists: M Rajgopal Acharya, Piyush Upadhyay, Shabeerali TU, Vibhor Borkar

Treatment Advances: IBAT inhibitors – clinical evidence, real-world experience, and their impact on delaying or avoiding liver transplantation

12:11 - 12:19 Talk

Speaker: Rajeev Khanna

Moderated Q&A

12:19 - 12:23

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